Changed distribution of sodium channels along demyelinated axons.
نویسندگان
چکیده
منابع مشابه
Increase of sodium channels in demyelinated lesions of multiple sclerosis.
Redistribution of sodium channels along demyelinated pathways in multiple sclerosis (MS) could be an important event in restoring conduction prior to other reparative mechanisms such as remyelination. Sodium channels in human multiple sclerosis lesions were identified by quantitative light microscopic autoradiography using tritiated saxitoxin (STX), a highly specific sodium channel ligand. Demy...
متن کاملConduction in segmentally demyelinated mammalian central axons.
The prominent symptoms associated with central demyelinating diseases such as multiple sclerosis (MS) are primarily caused by conduction deficits in affected axons. The symptoms may go into remission, but the mechanisms underlying remissions are uncertain. One factor that could be important is the restoration of conduction to affected axons, but it is not known whether demyelinated central axon...
متن کاملSingle channel characterization of multiple types of potassium channels in demyelinated Xenopus axons.
Single channel currents in internodes of demyelinated Xenopus axons were measured with the gigaseal patch-clamp technique. Demyelination induced by injected lysolecithin allows the entire internodal axolemma to be accessible to a patch electrode. Four classes of K+ channels in this region were characterized. A Ca(2+)-activated K+ channel [K(Ca)] with a single channel conductance of 235 pS was f...
متن کاملSlow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons.
Ectopic action potentials can arise at regions of axonal demyelination, and are believed to contribute to a range of symptoms in patients with demyelinating conditions such as multiple sclerosis. The mechanism(s) by which the ectopic impulses are generated are uncertain. We have previously shown that such ectopic activity can result from inward potassium currents. Paradoxically, the potassium c...
متن کاملMolecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger.
Although voltage-gated sodium channels are known to be deployed along experimentally demyelinated axons, the molecular identities of the sodium channels expressed along axons in human demyelinating diseases such as multiple sclerosis (MS) have not been determined. Here we demonstrate changes in the expression of sodium channels in demyelinated axons in MS, with Nav1.6 confined to nodes of Ranvi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1990
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.87.17.6777